Toxicity of Nitrazepam (Mogadon)
نویسندگان
چکیده
منابع مشابه
Nitrazepam (Mogadon) in blood serum and urine and librium in urine.
A method is described for the determination of nitrazepam and its reduced product in blood serum and urine. The metabolite, the reduced product, is the principal substance to be encountered in these fluids. A method is also described for the determination of librium (and the lactam) in urine.
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Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).
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1 To assess the potential hazards of nitrazepam therapy of insomnia in the elderly, adverse reactions to nitrazepam were studied in 2111 hospitalized medical patients who received the drug. 2 Manifestations of unwanted central nervous system (CNS) depression (such as drowsiness or 'hangover') were reported in 49 nitrazepam recipients (2.3%), and signs of unwanted CNS stimulation (such as nightm...
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The therapeutic results obtained with Nitrazepam in 30 children with emotional disorders between 4 and 14 years of age are reported, 17 children with habit disorders, 6 with behaviour, 5 with personality and 2 with Neurosis. Employing a flexible dosage schedule, a dose of 1/4 tablet to 1 tablet of 5 mg. Nitrazepam once to thrice daily was effective and safe. 24 of the 30 children (80%) showed r...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1987
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-1-3-6